2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

Related Products

PDF 32.36 MB

Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-103153R
    SB 204741 (Standard) 152239-46-8 98%
    SB 204741 (Standard) is the analytical standard of SB 204741. This product is intended for research and analytical applications. SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.
    SB 204741 (Standard)
  • HY-103157R
    PD146176 (Standard) 4079-26-9 98%
    PD146176 (Standard) is the analytical standard of PD146176. This product is intended for research and analytical applications. PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
    PD146176 (Standard)
  • HY-103171R
    BAY 60-6583 (Standard) 910487-58-0 98%
    BAY 60-6583 (Standard) is the analytical standard of BAY 60-6583. This product is intended for research and analytical applications. BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50?= 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.
    BAY 60-6583 (Standard)
  • HY-103181R
    N6-Cyclopentyladenosine (Standard) 41552-82-3 98%
    N6-Cyclopentyladenosine (Standard) is the analytical standard of N6-Cyclopentyladenosine (HY-103181). This product is intended for research and analytical applications. N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures.
    N6-Cyclopentyladenosine (Standard)
  • HY-103185R
    CCPA (Standard) 37739-05-2 98%
    CCPA (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction.
    CCPA (Standard)
  • HY-103193R
    NKH477 (Standard) 138605-00-2 98%
    NKH477 (Standard) is the analytical standard of NKH477 (HY-103193). This product is intended for research and analytical applications. NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts.
    NKH477 (Standard)
  • HY-103200R
    SR59230A hydrochloride (Standard) 1135278-41-9
    SR59230A hydrochloride (Standard) is the analytical standard of SR59230A hydrochloride (HY-103200). This product is intended for research and analytical applications. SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
    SR59230A hydrochloride (Standard)
  • HY-103214R
    Bucindolol (Standard) 71119-11-4 98%
    Bucindolol (Standard) is the analytical standard of Bucindolol. This product is intended for research and analytical applications. Bucindolol is a β1-adrenergic receptor blocker, with intrinsic sympathomimetic activity, used in the research of heart failure.
    Bucindolol (Standard)
  • HY-103227R
    Desidustat (Standard) 1616690-16-4 98%
    Desidustat (Standard) is the analytical standard of Desidustat. This product is intended for research and analytical applications. Desidustat is an orally active HIF hydroxylase inhibitor. Desidustat can be used for the research of various disorders including anemia of different types and conditions associated with ischemia/hypoxia.
    Desidustat (Standard)
  • HY-103263R
    PSB-06126 (Standard) 1052089-16-3
    PSB-06126 (Standard) is the analytical standard of PSB-06126 (HY-103263). This product is intended for research and analytical applications. PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the Ki values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC50 value of 7.76 μM and a Ki value of 4.39 μM.
    PSB-06126 (Standard)
  • HY-103293B
    Lys-Bradykinin tetraacetate 84640-50-6 98%
    Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation.
    Lys-Bradykinin tetraacetate
  • HY-103307R
    FPL64176 (Standard) 120934-96-5 98%
    FPL64176 (Standard) is the analytical standard of FPL64176. This product is intended for research and analytical applications. FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM.
    FPL64176 (Standard)
  • HY-103315R
    Bepridil hydrochloride (Standard) 68099-86-5 98%
    Bepridil hydrochloride (Standard) is the analytical standard of Bepridil hydrochloride. This product is intended for research and analytical applications. Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
    Bepridil hydrochloride (Standard)
  • HY-103315S
    Bepridil-d5 hydrochloride 98%
    Bepridil-d5 (hydrochloride) (CERM 1978-d5) is deuterium labeled Bepridil hydrochloride. Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
    Bepridil-d5 hydrochloride
  • HY-103316R
    trans-Ned 19 (Standard) 1354235-96-3
    trans-Ned 19 (Standard) is the analytical standard of trans-Ned 19 (HY-103316). This product is intended for research and analytical applications. trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis.
    trans-Ned 19 (Standard)
  • HY-103334R
    MAFP (Standard) 188404-10-6 98%
    MAFP (Standard) is the analytical standard of MAFP (HY-103334). This product is intended for research and analytical applications. MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
    MAFP (Standard)
  • HY-103346R
    MMPSI (Standard) 220509-74-0
    MMPSI (Standard) is the analytical standard of MMPSI (HY-103346). This product is intended for research and analytical applications. MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection.
    MMPSI (Standard)
  • HY-103372R
    GSK264220A (Standard) 685506-42-7
    GSK264220A (Standard) is the analytical standard of GSK264220A (HY-103372). This product is intended for research and analytical applications. GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.
    GSK264220A (Standard)
  • HY-103410R
    Carmoxirole hydrochloride (Standard) 115092-85-8 98%
    Carmoxirole (hydrochloride) (Standard) is the analytical standard of Carmoxirole (hydrochloride). This product is intended for research and analytical applications. Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo.
    Carmoxirole hydrochloride (Standard)
  • HY-103460R
    IRL 2500 (Standard) 169545-27-1
    IRL 2500 (Standard) is the analytical standard of IRL 2500 (HY-103460). This product is intended for research and analytical applications. IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
    IRL 2500 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity